TECHNOLOGY FOR IMPROVED ORAL DELIVERY OF ANTI-HIV DRUGS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
18945
Agency Tracking Number:
18945
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
540 Avis Drive, Ann Arbor, MI, 48108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Glen D Leesman
(313) 663-4233
Business Contact:
() -
Research Institute:
n/a
Abstract
THE LONG-TERM OBJECTIVE IS TO DEVELOP AN ORAL DRUG DELIVERY STRATEGY AND TECHNOLOGY BASE TO INCREASE THE EXTENT OF ABSORPTION AND DECREASE THE VARIABILITY OF THE ABSORPTION OF NUCLEOTIDE ANTIVIRAL DRUG ANALOGS IN HUMANS. 2', 3'-DIDEOXYINOSINE (VIDEX TM, DDI) IS A PURINE NUCLEOSIDEDRUG ANALOG THAT IS A POTENT AND SELECTIVE INHIBITOR OR HIV REVERSE TRANSCRIPTASE. DDI IS EXTREMELY UNSTABLE IN THE ACIDIC CONDITIONS OF THE STOMACH. HOWEVER, EVEN WHEN DDI IS GIVEN WITH ANTACIDS THE ABSORPTION IS HIGHLY VARIABLE IN HUMANS. DURING PHASE I, A DRUG DELIVERY STRATEGY WILL BE DEVELOPED BASED ON THE RESULTS OF INTESTINAL PERFUSION EXPERIMENTS IN RATS ANDON THE PHYSICO-CHEMICAL PROPERTIES OF DDI. BASED ON THOSE RESULTS A DOSAGE FORM FOR DDI WILL BE DEVELOPED AND TESTED IN DOGS. THE POTENTIAL BENEFITS OF IMPROVED DDI ORAL DELIVERY TO AIDS/ARC PATIENTS ARE A DECREASE IN SIDE EFFECTS AND AN IMPROVED AND CONSISTENT DELIVERY OF DDI LEADING TO REPRODUCIBLE PHARMACOKINETICS AND PHARMACODYNAMIC RESPONSE. THIS STRATEGY COULD REDUCE PATIENT TOXICITY, THUS IMPROVING AND PROLONGING ORAL THERAPY.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government