DESIGN AND EVALUATION OF A COMPOUND TRACHEAL PROSTHESIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$453,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
7221
Agency Tracking Number:
7221
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
520 Wakara Way, Salt Lake City, UT, 84108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Richard E Hoffer Dvm
(801) 583-3600
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PROPOSED STUDY IS DESIGNED TO DEVELOP AND EVALUATE A METHOD OF REPLACING THE TRACHEA WITH A COMPOUND PROSTHESIS THAT WILL BE EPITHELIZED AT THE TIME OF IMPLANTATION BY TISSUE CULTURE OF BUCCAL MUCOSA OR A FREE GRAFT OF TRACHEAL MUCOSA. HEALING OF THE CERVICAL TRACHEA TO TWO TYPES OF PROSTHESES WILL BE EVALUATED IN DOGS. BOTH TYPES WILL HAVE A RIGID POLYETHYLENE OUTER LAYER AND A MIDDLE LAYER OF ATELOCOLLAGEN. THE INNER LAYER, OR TYPE 1 PROSTHESIS, WILL CONSIST OF BUCCAL MUCOSAL TISSUE CULTURED ONTO THE COLLAGEN LAYER. THE TYPE 2 PROSTHESIS WILL HAVE A FREE GRAFT OF TRACHEAL MUCOSA. THE PROSTHESES WILL BE EVALUATED AT VARIOUS POSTIMPLANTATION TIMES OF UP TO 60 DAYS. EVALUATIONOF THE SURGICAL SITES FOR GRAFTED AND CULTURED MUCOSAL HEALING, PROLIFERATION, CONNECTIVE TISSUE GROWTH, SCARRING, INFECTION, AND REJECTION WILL BE PERFORMED BY GROSS EXAMINATION AND HISTOPATHOLOGICAL METHODS.

* information listed above is at the time of submission.

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