MICROELECTRODES FOR THE DETERMINATION OF NEUROREGULATORS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$323,579.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
14004
Agency Tracking Number:
14004
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 736, New Orleans, LA, 70148
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Glenn J Lubrano
(504) 885-8443
Business Contact:
() -
Research Institute:
n/a
Abstract
OVER THE LAST 20 YEARS, MANY NEUROREGULATORS HAVE BEEN IDENTIFIED AND SIGNIFICANT PROGRESS HAS BEEN MADE IN IDENTIFYING THE MOLECULAR BASIS OF NEUROTRANSMISSION. THE IN VIVO DYNAMICS OF SEVERAL NEUROCHEMICAL EVENTS HAVE BEEN MONITORED USING AMPEROMETRIC MICROELECTRODES, BUT THIS APPROACH IS HINDERED BY THE REALTIVELY POOR SELECTIVITY OF THESE ELECTRODES. IN THIS PROJECT, ELECTRODES WITH EXCELLENT SELECTIVITIES WILL BE DEVELOPED BY INCORPORATING A THIN LAYER OF IMMOBILIZED ENZYME AND OTHER PROTECTIVE COATINGS INTO THE MICROELECTRODE. SUCH ELECTRODES WOULD ALLOW THE IN VIVO DETERMINATION OF NONELECTROACTIVE SPECIES FOR THE FIRST TIME. INITIALLY, AN ELECTRODE FOR THE DETERMINATION OF THE POTENT NEUROEXCITATORY AMINO ACID, GLUTAMATE, WAS DEVELOPED, BECAUSE IT HAS BEEN IDENTIFIED IN MANY NEURONAL PATHWAYS ANDIS NORMALLY PRESENT IN FAIRLY HIGH CONCENTRATIONS. THE SPATIAL, TEMPORAL, AND ANALYTICAL CHARACTERISTICS OF THE ELECTRODES WILL BE IMPROVED, AND MICROELECTRODES FOR OTHER COMPOUNDS IMPORTANT IN NEUROREGULATION WILL BE DEVELOPED IN PHASE II.

* information listed above is at the time of submission.

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