STTR Phase I: Monolithic Multiwavelength Blue-to-IR LED for Biomedical Diagnostics

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$149,761.00
Award Year:
2007
Program:
STTR
Phase:
Phase I
Contract:
0712295
Award Id:
84933
Agency Tracking Number:
0712295
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
920 Main Campus Drive, 6745 HOLLISTER AVENUE, Raleigh, NC, 27606
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
784437100
Principal Investigator:
Steven LeBoeuf
Dr
(919) 793-6977
leboeuf@valencell.com
Business Contact:
Steven LeBoeuf
PhD
(919) 793-6977
leboeuf@valencell.com
Research Institution:
North Carolina State Univ
John F Muth
Compus Box 7514
Raleigh, NC, 27695-2470
(919) 513-2982
Nonprofit college or university
Abstract
This Small Business Technology Transfer (STTR) Phase I project will demonstrate the feasibility of a novel multi-wavelength light-emitting diode (LED) for transdermal health monitoring of various blood metabolites simultaneously in real time. With independent control of up to 12 spectrally narrow wavelengths, ranging from deep-UV to mid-IR, from a single 1 mm2 LED die, the company's compact multi-wavelength LED will revolutionize traditional pulse oximetry with unprecedented functionality at a significantly lower cost. In contrast with traditional dual-wavelength pulse oximetry, which primarily measures the ratio of oxygenated to deoxygenated blood, the proposed multi-wavelength LED will enable the real-time analysis several additional metabolites critical to health monitoring via the same noninvasive paradigm. Furthermore, combining 12 LEDs into one self-aligned device precludes the need for expensive packaging and complex optical alignment.The medical impact of dual-wavelength pulse oximetry, in both saving lives and reducing healthcare costs, has encouraged the development of broader platforms using additional optical wavelengths. Incorporating 3 or more independently controlled wavelengths has been shown to enable the real-time monitoring of multiple health factors while further reducing readout errors - thus saving more lives. Beyond blood oxygen monitoring, a real-time noninvasive assessment of renal and hepatic health can be realized by integrating several wavelengths in the same clinically accepted pulse oximetry paradigm. The proposed multi-wavelength single-die approach surmounts these limitations by providing independent control of several wavelengths from a single, self-aligned, compact LED. Integrating these advanced, cost-effective optical sources into traditional pulse oximetry opens up new markets in noninvasive metabolic monitoring for paramedics, physical therapists, drug discovery, and home healthcare. As a spectroscopic source, other applications include air-quality/pollution monitoring and agricultural/industrial controls.

* information listed above is at the time of submission.

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