THE USE OF A ONE STEP IMMUNOASSAY FOR DETECTING INFECTIOUS/TOXIC AGENTS

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$48,226.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
6609
Agency Tracking Number:
6609
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
36 S Chester, Pasadena, CA, 91106
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DONALD E ROUNDS
(818) 795-4343
Business Contact:
() -
Research Institution:
n/a
Abstract
A RECENTLY DEVELOPED ONE STEP IMMUNOLOGICAL ASSAY SYSTEM IS BEING PROPOSED TO ADDRESS THE NEED FOR A RAPID METHOD FOR IDENTIFYING INFECTIOUS AGENTS THAT HAVE MILITARY IMPORTANCE. THE TEST SYSTEM CONSISTS OF A DIPSTICK AND A SEALED ENVELOPE CONTAINING LYOPHILIZED PRECOLORED REACTANTS. THE REACTANTS CONSIST OF MOLECULAR COMPLEXERS OF ANTIBODY MOLECULES WHICH ARE PREAMPLIFIED WITH COLORED AVIDIN/BIOTIN RESIDUES. THE TEST IS PERFORMED BY THE ADDITION OF TWO DROPS OF THE TEST SOLUTION, TO SOLUBILIZE THE REACTANTS AND PERMIT INTERACTION FO THE ANTIBODIES WITH THE ANTIGEN MOLECULES, IF PRESENT. COLOR IS DEPOSITED ON THE MEMBRANE OF THE INSERTED DIPSTICK TO FORM EITHER A PLUS OR MINUS SIGN DURING AN INITIAL 15 MINUTE INCUBATION PERIOD, TO INDICATE THE PRESENCE OR ABSENCE OF THE ANTIGEN. THE TEST SYSTEM IS PORTABLE, ECONOMICAL, EASY TO USE AND SENSITIVE TO LESS THAN A NANOGRAM OF ANTIGEN.

* information listed above is at the time of submission.

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