DEVELOPMENT OF A MICROVASCULATURE ENDOTHELIAL CELL MEDIUM

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,981.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
13733
Agency Tracking Number:
13733
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 8780, Albany, NY, 12208
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Wei-jia Li
(518) 395-2196
Business Contact:
() -
Research Institute:
n/a
Abstract
THE LONG-TERM CULTIVATION OF MICROVASCULATURE ENDOTHELIAL CELLS IS NOT COMMON. THESE CELLS ARE IMPORTANT IN STUDIES OF INFLAMMATION, NEOVASCULARIZATION, AND SEEDING OF PROSTHETIC GRAFTS. FAILURE TO GROW MICROVASCULATURE ENDOTHELIAL CELLS FOR MANY POPULATION DOUBLINGS IS DUE, IN PART, TO THE USE OF SUPPLEMENTED MEDIA THAT WERE DEVELOPED AND OPTIMIZED FOR THE CULTIVATION OF LARGE-VESSEL ENDOTHELIAL CELLS. VEC TEC, INC., IS DEVELOPING A MEDIUM THAT WILL OPTIMIZE THEGROWTH OF MICROVASCULATURE ENDOTHELIAL CELLS AND ALLOW FOR THE EXPANSION OF CELL POPULATIONS ISOLATED FROM VARIOUS COMPLEX TISSUES. IT HAS BEEN FOUND THAT THE COMBINATION OF CHONDROITIN SULFATE AND ENDO GRO, A RETINAL-DERIVED ENDOTHELIAL CELL GROWTH FACTOR, ACTS SYNERGISTICALLY TO PROMOTE THE GROWTH OF MICROVASCULATURE ENDOTHELIAL CELLS FROM MURINE HEARTS. VEC TEC, INC.'S, MEDIUM PROMOTES ENHANCED GROWTH AND REPLICATION TIMES. THIS RESEARCH WILL EVALUATE THE ABILITY OF THIS MUCOPOLYSACCHARIDE AND ENDO GRO-SUPPLEMENTED MEDIUM TO SUPPORT THE GROWTH OF MURINE MICROVASCULATURE ENDOTHELIAL CELLS FROM ADDITIONAL ANATOMIC SITES AND DETERMINE IF THIS MEDIUM CAN EXTEND THE IN VITRO LIFE SPAN. THE OBJECTIVE IS TO DEVELOP A COMMERCIAL TISSUE CULTURE MEDIUM FOR THE CULTIVATION OF MICROVASCULATURE ENDOTHELIAL CELLS.

* information listed above is at the time of submission.

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