Development of an Integrated Database Management System for Biodefense Research

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W81XWH-07-C-0075
Agency Tracking Number: C071-114-0150
Amount: $69,946.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD07-114
Solicitation Number: 2007.1
Solicitation Year: 2007
Award Year: 2007
Award Start Date (Proposal Award Date): 2007-05-10
Award End Date (Contract End Date): 2007-11-09
Small Business Information
5004 Lehigh Avenue, College Park, MD, 20740
DUNS: 094078958
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 Christopher Larsen
 Senior Scientist
 (240) 737-1625
Business Contact
 Mike Bearman
Title: General Counsel
Phone: (240) 737-1650
Research Institution
This Phase I SBIR grant proposal is submitted in response to the need for a database resource that can house, import, query, and manage data from diagnostics related to biological threat detection. Such a project for military force health protection requires the creation of a flexible, relational database resource, with dedicated import tools, query systems, and data management tools. This proposal focuses on threat detection, species identification, and data management. It addresses organisms such as Anthrax, Clostridium, Yersinia, Variola, Francisella, Ebolavirus, Lassavirus, Brucella, Salmonella, E. coli, Coxiella, Burkholderia, Vibrio, Cryptosporidium, Ricinus, Rickettsia, encephalitis virii, and others. We will build a robust, extensible web application and relational database resource, called BioDefBase(TM), which uses novel biological computational analysis tools, and is focused on data used to identify pathogens, such as that from microarrays, host expression response assays, protein arrays, PCR experiments, and immunological approaches such as ELISA. The BioDefBase analysis tools will be focused on specific data types, and on visualizations designed to assist the scientist and technician in assay interpretation, experiment design, pathogen identification, and threat detection. With the creation of BioDefBase, researchers and technicians will have a flexible database solution to store, search, manage, and maintain diagnostic bioassay data.

* Information listed above is at the time of submission. *

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