THE CULTURE ENVIRONMENT IN WHICH A MAMMALIAN CELL IS MAINTAINED CAN PROFOUNDLY INFLUENCE ITS STATE OF DIFFERENTIATION AND ITS LONGEVITY AS WELL AS ITS GROWTH RATEAND PRODUCTIVITY.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
4680
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Verax Corpon
Etna Road, Hc 61, Box 6, Lebanon, NH, 03766
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
EDWARD G HAYMAN
PRINCIPAL INVESTIGATOR
(603) 448-4445
Business Contact:
() -
Research Institution:
n/a
Abstract
THE CULTURE ENVIRONMENT IN WHICH A MAMMALIAN CELL IS MAINTAINED CAN PROFOUNDLY INFLUENCE ITS STATE OF DIFFERENTIATION AND ITS LONGEVITY AS WELL AS ITS GROWTH RATEAND PRODUCTIVITY. VERAX CORPORATION HAS DEVELOPED A SYSTEM FOR THE MASS CULTURE OF MAMMALIAN CELLS AND HAS CHOSEN LARGE-SCALE PRODUCTION OF MONOCLONAL ANTIBODIES FOR ITS DEVELOPMENTAL WORK. THE CELL CULTURE SYSTEM USES A BIOMATRIX FOR THE IMMOBILIZATION OF CELLS. THE MATRIX IS MAINTAINED DURING THE OPERATION AS A FLUIDIZED BED IN A BIOREACTOR OF VERAX DESIGN. THE SYSTEM IS CAPABLE OF CONTINUOUS OPERATION AND HAS BEEN RUN FOR MONTHS WITHOUT INTERRUPTION. IT IS MOST PRODUCTIVE WHEN THE CELL DENSITY WITHIN THE BIOMATRIX IS MAXIMIZED. THIS APPLICATION PROPOSES THREE MODIFICATIONS OF THE BIOMATRIX THAT WILL REDUCE THE TIME IT TAKES TO REACH THIS DESIRED DENSITY AND MAY RESULT IN ACHIEVING HIGHER DENSITIES THAN ARE NOW OBSERVED. WHILE THIS STUDY WILL UTILIZE HYBRIDOMA CELLS, THE BIOMATRIX MODIFICATIONS ARE NOT LIMITED TO THIS CELL TYPE.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government