THE CULTURE ENVIRONMENT IN WHICH A MAMMALIAN CELL IS MAINTAINED CAN PROFOUNDLY INFLUENCE ITS STATE OF DIFFERENTIATION AND ITS LONGEVITY AS WELL AS ITS GROWTH RATEAND PRODUCTIVITY.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4680
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Verax Corpon
Etna Road, Hc 61, Box 6, Lebanon, NH, 03766
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 EDWARD G HAYMAN
 PRINCIPAL INVESTIGATOR
 (603) 448-4445
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE CULTURE ENVIRONMENT IN WHICH A MAMMALIAN CELL IS MAINTAINED CAN PROFOUNDLY INFLUENCE ITS STATE OF DIFFERENTIATION AND ITS LONGEVITY AS WELL AS ITS GROWTH RATEAND PRODUCTIVITY. VERAX CORPORATION HAS DEVELOPED A SYSTEM FOR THE MASS CULTURE OF MAMMALIAN CELLS AND HAS CHOSEN LARGE-SCALE PRODUCTION OF MONOCLONAL ANTIBODIES FOR ITS DEVELOPMENTAL WORK. THE CELL CULTURE SYSTEM USES A BIOMATRIX FOR THE IMMOBILIZATION OF CELLS. THE MATRIX IS MAINTAINED DURING THE OPERATION AS A FLUIDIZED BED IN A BIOREACTOR OF VERAX DESIGN. THE SYSTEM IS CAPABLE OF CONTINUOUS OPERATION AND HAS BEEN RUN FOR MONTHS WITHOUT INTERRUPTION. IT IS MOST PRODUCTIVE WHEN THE CELL DENSITY WITHIN THE BIOMATRIX IS MAXIMIZED. THIS APPLICATION PROPOSES THREE MODIFICATIONS OF THE BIOMATRIX THAT WILL REDUCE THE TIME IT TAKES TO REACH THIS DESIRED DENSITY AND MAY RESULT IN ACHIEVING HIGHER DENSITIES THAN ARE NOW OBSERVED. WHILE THIS STUDY WILL UTILIZE HYBRIDOMA CELLS, THE BIOMATRIX MODIFICATIONS ARE NOT LIMITED TO THIS CELL TYPE.

* information listed above is at the time of submission.

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