Spectroscopic Imaging Technology for THz Biosensor Integrated with a Lab-on-Chip Platform

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911NF-07-C-0055
Agency Tracking Number: C071-104-0049
Amount: $99,273.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: CBD07-104
Solicitation Number: 2007.1
Small Business Information
221 Cottonwood Dr., Barboursville, VA, 22923
DUNS: 789962656
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Tatyana Khromova
 (434) 985-7459
Business Contact
 Tatyana Khromova
Title: president
Phone: (434) 985-7459
Email: tak@estart.com
Research Institution
In this Phase I SBIR project we propose a new imaging mechanism for sub-wavelength THz spectroscopy based on a very strong enhancement of electromagnetic field of the THz radiation at the edges of periodic semiconductor structure. Our recent theoretical study showed THz radiation power enhancement ~1100 with the half power width around the slot edges ~500 nm. Such strongly enhanced local electromagnetic field can potentially be used for the development of novel biophotonic spectroscopic and imaging sensors with increased radiation coupling to biomaterial, leading to a substantial increase in detection sensitivity and spatial resolution and allowing THz spectroscopy and imaging at the micron-submicron scale. The major goal of this phase I of SPIR project will be to confirm experimentally the expected effect of increasing electric field in a nanosize regions and to demonstrate the feasibility of application a proposed imaging mechanism integrated with a “lab-on-a chip” device for subwavelength THz spectroscopic microscope. The other goal of the proposed project is to improve controlled conditions for more uniformed orientation of biological materials. The initial phase I of SPIR project will include preliminary experimental investigations of fluidic-chip processing of biomaterials and/or bio agents. In the phase II of SBIR project, the proposed imaging technology will be further optimized and will be integrated into a pre-existing or a new developed fluidic platform to be used in THz spectroscopy and microscopy.

* Information listed above is at the time of submission. *

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