Spectroscopic Imaging Technology for THz Biosensor Integrated with a Lab-on-Chip Platform

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911NF-08-C-0049
Agency Tracking Number: C071-104-0049
Amount: $749,857.00
Phase: Phase II
Program: SBIR
Awards Year: 2008
Solicitation Year: 2007
Solicitation Topic Code: CBD07-104
Solicitation Number: 2007.1
Small Business Information
221 Cottonwood Dr., Barboursville, VA, 22923
DUNS: 789962656
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Tatyana Khromova
 (434) 985-7459
Business Contact
 Tatyana Khromova
Title: President
Phone: (434) 985-7459
Email: t.khromova@vibratess.com
Research Institution
In the Phase I CBD SBIR project, Vibratess proposed and confirmed a new imaging mechanism for subwavelength THz spectroscopy based on very strong enhancement of electromagnetic field of THz radiation at the edges of periodic semiconductor structure. The technology to fabricate an integrated miniature detector assembly (with a Schottky diode, a circuit and a nano-size antenna to probe radiation transmitted through tested material), a periodic structure and a microfluidic cell was successfully demonstrated. In the Phase II, a new imaging mechanism will be used to develop and fabricate a complete working prototype of THz spectroscopic sensor system. We plan to build a simple, all optical, appertureless, sub-wavelength transmission THz sensor with the spatial resolution much below the diffraction limit. Two central components of a proposed sensor, including microdetector assembly and microfluidic channel chip for a biomaterial will be integrated with a THz source through the optical focusing system and read-out circuitry. The major breakthrough of this work will be development and fabrication of inexpensive microfluidic chip integrated with a thin film grating to dramatically enhance sensitivity and spatial resolution. The sensor integrated with a “lab-on-a chip” device for sub-wavelength THz spectroscopic imaging within the 10-25 cm-1 spectral range will be capable to collect THz-frequency spectroscopic signatures from microscopic biological structures.

* Information listed above is at the time of submission. *

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