Innovative Laser Spectroscopic Approach for Breath Isoprene Detection

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,003.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43RR024255-01
Agency Tracking Number:
RR024255
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
VISTA PHOTONICS, INC.
VISTA PHOTONICS, INC., 67 CONDESA RD, SANTA FE, NM, 87508
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
134161533
Principal Investigator:
JOERG KUTZNER
(505) 466-3953
JKUTZNER@VISTAPHOTONICS.COM
Business Contact:
JEFFREY PILGRIM
() -
jpilgrim@vistaphotonics.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Breath tests are increasingly entering into medical diagnostics because of their non-invasive nature. However, a substantial breakthrough in breath testing is hampered by available instrumentation that is bulky, expensi ve and often not capable of real- time analysis. Isoprene is a volatile organic compound present in human breath. This endogenously formed substance is an indicator with non-invasive diagnostic potential. It has been related to cholesterol biosynthesis and may be used for mass screening of lipid disorders. Significantly, it has the potential to be applied in cancer screening. Vista Photonics, Inc. proposes to develop a compact, real-time medical isoprene breath analyzer. A specially designed laser source ba sed on an external cavity diode laser will be developed. A derivative photoacoustic spectroscopy approach will be applied to achieve the required selectivity. This new optical instrument will allow selective determination of the isoprene concentration whil e suppressing other interfering breath components. This enabling feature will allow the analysis of untreated breath samples, which substantially reduces instrument complexity. The proposed instrument platform is especially suited to be applied for the sel ective optical detection of larger molecules possessing broad absorption bands. The high performance detection of these molecules may find widespread application beyond medical applications. The development of a high performance respiratory analyzer for de tecting the critical breath component isoprene is proposed. This non-invasive medical diagnostics tool may be used for mass screening of lipid disorders and as well as cancer screening.

* information listed above is at the time of submission.

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