Advanced Optical Platform for Routine Renal Disease Management

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43DK082048-01
Agency Tracking Number: DK082048
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solicitation Year: 2008
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Small Business Information
DUNS: 134161533
HUBZone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 (505) 466-3953
Business Contact
Phone: (505) 466-3953
Research Institution
DESCRIPTION (provided by applicant): This project will determine the performance and operating specifications for a low-cost optical ammonia sensor for medical applications. Ammonia in human breath has been established as a significant biomarker with high potential for treating kidney and liver diseases as well as detection of bacterial infections. Widespread application of breath tests is currently hampered by the lack of availability of small, portable, cost- effective, highly accurate and reliable sensor s. This new sensor will address this need. It will allow the detection of ammonia in untreated breath at medically relevant concentrations ranging from 10 parts-per-billion to 10 parts-per-million. The proposed ammonia breath analyzer combines DPSS lasers with ultra-sensitive photoacoustic spectroscopy operating in a compact and simple analysis cell. This combination provides a unique tool for ammonia detection that is user friendly with a moderate price point. The proposed instrumentation platform shall al low widespread distribution of ammonia breath testing. PUBLIC HEALTH RELEVANCE: The development of a high performance respiratory analyzer for detecting the critical breath component ammonia is proposed. The analyzer is suited for broad noninvasive screeni ng for incipient kidney failure, kidney function monitoring in at- risk populations, treatment of kidney diseases, management of liver cirrhosis, detection of H. pylori infection as well as applications in sports medicine.

* Information listed above is at the time of submission. *

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