Highly Parallel AIDS Assays Using A Microfluidic Flow Cell Array Integrated with

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI083117-01
Award Id:
93426
Agency Tracking Number:
AI083117
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4909 BROWN VILLA COVE, SALT LAKE CITY, UT, 84123
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
171205177
Principal Investigator:
BRUCEGALE
(801) 585-5944
BRUCE.GALE@UTAH.EDU
Business Contact:
JOSHECKMAN
() -
bruce@microfl.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop a multiplex label free platform for high-throughput HIV specific serum antibody detection of patient samples. To help Wasatch Microfludics reach this ultimate goal, this p roposal will address the feasibility of performing high throughput label free detection of serum antibodies to a variety of HIV proteins through the application of a novel microfluidic spotting technology to available Surface Plasmon Resonance (SPR) array platforms. Specifically, a microfluidic flow cell array will be adapted for work with real world samples such as plasma, serum, and cell lysates. The flow cell array will have 48 channels and address an array of spots designed to support ongoing pre- cli nical trials in non-human primates as well as HIV vaccine trials in humans. The development of a low cost, high throughput, multiplex assay to assess the development of humoral immune responses following vaccine administration is essential for comprehensiv e immunomonitoring. PUBLIC HEALTH RELEVANCE: The successful completion of this proposal will create a dramatic improvement in the ability to conduct multiplex SPR-based assays in drug discovery and proteomic research. On a greater scale, this will lead to improved diagnostic tools and reductions in the cost and time of drug development, by significantly improving the throughput of label free screening.

* information listed above is at the time of submission.

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