SYSTEM FOR RAPID ANALYSIS OF SINGLE CELLS

Award Information
Agency:
Department of Energy
Branch
n/a
Amount:
$49,849.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
2530
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Wedding & Associates, Inc.
P.o. Box 1756, Fort Collins, CO, 80522
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR. JAMES B. WEDDING
PRINCIPAL INVESTIGATOR
(303) 221-0678
Business Contact:
() -
Research Institution:
n/a
Abstract
THERE EXISTS A NEED TO DEVELOP NEW INSTRUMENTATION THAT CAN PROVIDE INFORMATION ABOUT SIZE, SHAPE, AND IDENTITIES OF INDIVIDUAL CELLS IN A FLOW SYSTEM THROUGH A RAPID, IN-SITU, OPTICAL ANALYSIS. THE OBJEC- TIVES OF THIS EFFORT ARE TO IDENTIFY THE SYSTEM RE- QUIREMENTS, PROJECT THE TECHNICAL FEASIBILITY OF THE DEVELOPED CONCEPTS, AND DESIGN A PROTOTYPE SYSTEM, INCLUDING A PARTICLE INJECTING SYSTEM, AN OPTICAL SYS- TEM, AND A HIGH-SPEED DATA ACQUISITION SYSTEM. THIS WILL MEASURE THE DIFFERENTIAL SCATTERING PATTERNS OF INDIVIDUAL CELLS AT TWO LASER WAVELENGTHS IN AT LEAST THREE DIFFERENT SCATTERING PLANES. THE OPTICAL SYSTEM INCLUDES ELLIPSOIDAL REFLECTORS AND CIRCULAR ARRAY DETECTORS TO SCAN 2 SCATTERING ANGLES IN A FINE ANGULAR RESOLUTION. PHASE I RESULTS ARE TO PROVIDE DE- TAILS OF SYSTEM DESIGN, HARDWARE IDENTIFICATION, AND THEORETICAL ANALYSIS THAT WILL DIRECT THE IMPLEMENTA- TION OF PHASE II-THE ACTUAL CONSTRUCTION OF THE SYSTEM.

* information listed above is at the time of submission.

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