Numerical Modeling of Therapeutic Ultrasound

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$73,922.00
Award Year:
1994
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 CA65255-1,
Award Id:
24911
Agency Tracking Number:
24911
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
4410 El Camino Real, Suite 110, Los Altos, CA, 94022
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Gregory Wojcik
(415) 949-3010
Business Contact:
() -
Research Institution:
n/a
Abstract
The objective is to develop, validate, and distribute numerical simulation software forcomprehensive computer modeling of therapeutic ultrasound. The principal application areas are focusedultrasound for noninvasive treatment of cancer and benign prostatic hypertrophy. Emphasis is ontherapy methods that minimize blood perfusion effects via relatively fast, localized heating of tissue.The principal modeling issue is rapid, nonlinear change in tissue and ultrasound propagation in the focus,requiring a combination of non linear thermal and ultrasound modeling for both continuous and transientmechanical waves. No comprehensive modeling capability of this type exists in the medical communitytoday. The analytical bases for this numerical simulation research are time-domain finite elementmethods. Temporal integration of the finite element equations provides complete linear or nonlinearsolutions of the ultrasound and bioheat equations in two-or three-dimensional (2D or 3D) domains thatconform to tissue boundaries. The aim is to develop the necessary software and make it accessible toall interested parties, both commercial and academic. The code will run on UNIX workstations and thenext generation of personal computers (Pentium and PowerPC). The foundation finite element code,PZFlex is fully operational and currently sold for transducer design.

* information listed above is at the time of submission.

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