Numerical Modeling of Therapeutic Ultrasound

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 CA65255-1,
Agency Tracking Number: 24911
Amount: $73,922.00
Phase: Phase I
Program: SBIR
Awards Year: 1994
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
Weidlinger Associates
4410 El Camino Real, Suite 110, Los Altos, CA, 94022
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Gregory Wojcik
 (415) 949-3010
Business Contact
Phone: () -
Research Institution
N/A
Abstract
The objective is to develop, validate, and distribute numerical simulation software forcomprehensive computer modeling of therapeutic ultrasound. The principal application areas are focusedultrasound for noninvasive treatment of cancer and benign prostatic hypertrophy. Emphasis is ontherapy methods that minimize blood perfusion effects via relatively fast, localized heating of tissue.The principal modeling issue is rapid, nonlinear change in tissue and ultrasound propagation in the focus,requiring a combination of non linear thermal and ultrasound modeling for both continuous and transientmechanical waves. No comprehensive modeling capability of this type exists in the medical communitytoday. The analytical bases for this numerical simulation research are time-domain finite elementmethods. Temporal integration of the finite element equations provides complete linear or nonlinearsolutions of the ultrasound and bioheat equations in two-or three-dimensional (2D or 3D) domains thatconform to tissue boundaries. The aim is to develop the necessary software and make it accessible toall interested parties, both commercial and academic. The code will run on UNIX workstations and thenext generation of personal computers (Pentium and PowerPC). The foundation finite element code,PZFlex is fully operational and currently sold for transducer design.

* information listed above is at the time of submission.

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