Enhanced Kidney Dialysis by Ultrasonic Transduction

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$90,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 DK49400-01,
Award Id:
29375
Agency Tracking Number:
29375
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3495 Winton Place, Bldg B, Rochester, NY, 14623
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Stephen Hine
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
The objective of this research is to improve the efficiency of kidney dialysis. Efficiency of massdetermined by clearance rate across the membrane. One of the primary restrictions to clearance is thcondition at the membrane surface which exists in either tube or channel. The aim is to increase effboundary layer, thus altering clearance of common metabolites such as sodium chloride, urea, creatinWe will create an "active" mixing to increase efficiency by utilizing low power ultrasonic energy toup boundary layers in the blood envelope, allowing more plasma and formed elements to contact membraAn ultrasonic transducer is coupled to parallel plate and hollow fiber dialyzers and then excited wispecific frequency ranges. Improved efficiency is determined by comparison of assay results of bloodfor ultrasonic versus non-ultrasonic (control) dialysis. Additionally, cellular damage is monitoredvalues of ultrasonic versus control dialysis. Coupling ultrasonic transducers to dialyzers should immanagement and reduce costs by diminishing the duration of kidney dialysis treatments.

* information listed above is at the time of submission.

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