Pump/Oxygenator for Pediatric Cardiopulmonary Support

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$75,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 HL53196-01A1,
Agency Tracking Number:
29498
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Whalen Biomedical, Inc.
5 Howland Street, Cambridge, MA, 02138
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Robert Whalen
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
The objective of this program is the development of an integrated pump/oxygenator for pediatric carsupport. The device employs an axial flow pump to produce secondary flows in a tubular membrane oxygworking pressure. The outflow from the oxygenator is then returned to the patient's circulation by acentrifugal pump which maintains the oxygenator pressure in a preset range regardless of the afterlousable for either venoarterial or venovenous bypass without modification. The automatic control systemploys fuzzy logic, and its operation will be transparent to the user so that comparatively untrainto operate the unit safely. The advantages of this two-stage pump system include a reduction in themade possible by improved gas transfer efficiency compared to conventional oxygenators; the eliminatreservoir and the need for passive siphon blood drainage; and a considerable reduction in the totalin contact with blood. Working prototypes will be constructed, and the membrane gas transfer efficieA determination of the index of hemolysis will also be made by operating the unit in a dosed mock cimeasuring the rate of generation of free plasma hemoglobin. Finally, the unit will be evaluated in vacute studies using 4 kg rabbits placed on venoarterial bypass for a period of 5-6 hours. Gas transfcaused by the device, and circulating platelet levels and platelet function will be examined.

* information listed above is at the time of submission.

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