MEMBRANE BASED ROLLER BOTTLE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44HL065977-02
Agency Tracking Number: HL065977
Amount: $1,287,376.00
Phase: Phase II
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
WILSON WOLF MANUFACTURING CORP., 151 SILVER LAKE RD NW, NEW BRIGHTON, MN, 55112
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JOHN WILSON
 (651) 628-9259
 WWMFGCORP@AOL.COM
Business Contact
 JOHN WILSON
Phone: (612) 628-9259
Email: WWMFGCORP@AOL.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): The culture of cells is currently undertaken to produce small and large quantities of cells and cell-secreted products, such as growth factors, enzymes, hormones, monoclonal antibodies, interferons, interleukins, vaccines, diagnostics, and viral vectors. A variety of commercially available membrane-based cell culture devices are available for the culture of mammalian ceils that have been adapted to suspension culture. A growing number of industrially important cells, however, are anchorage-dependent. Existing membrane-based devices lack the proper materials for adherent cell attachment and have sub-optimal surface areas. The membrane based roller bottle (MBRB) is a practical, cost effective culture device designed to meet this need and improve culture productivity. The MBRB combines the simplicity of the traditional roller bottle with membrane-based attributes. In the proposed Phase II studies, the MBRB will be optimized for the production of anchorage-dependent cells, cell-secreted products, and cellular transduction. Specific aims include a thorough mechanical design investigation followed by on-site and off-site application testing. The commercialization of a membrane-based family of research and clinical scale roller bottle devices is expected to lead to a more efficient use of biotechnology resources. At the completion of Phase II, the MBRB will be targeted to manufacturers of small and mid-scale culture devices for the production of cells or cell products for diagnostic and therapeutic applications.

* Information listed above is at the time of submission. *

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