RAPID BIOASSAY FOR SERUM AND URINE LEVELS OF AZIDOTHYMIDINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13658
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1990
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
820 E Haley St, Santa Barbara, CA, 93103
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Philip J Wyatt
 (805) 963-5409
Business Contact
Phone: () -
Research Institution
N/A
Abstract
AZIDOTHYMIDINE (AZT) IS ONE OF THE MOST EFFECTIVE DRUGS PRESENTLY AVAILABLE FOR ALLEVIATING SOME OF THE SYMPTOMS OF ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND DECREASING ITS MORTALITY RATE. RECENTLY, AZT HAS BEEN RECOMMENDED AND APPROVED FOR USE BY HIV-POSITIVE, ASYMPTOMATIC PATIENTS, INCLUDING CHILDREN. HOWEVER, ITS SIDE EFFECTS ARE OFTEN DANGEROUS. ALTHOUGH MUCH HAS BEEN LEARNED ABOUT THE DRUG AND ITS ACTIVITY AS AN ANTIVIRAL AGENT, VERY LITTLE IS KNOWNOF EFFECTIVE SERUM LEVELS OR THE RELATIONSHIP (IF ANY) BETWEEN SERUM LEVELS AND THE THERAPEUTIC INDEX. AT THE PRESENT TIME, ONLY HPLC AND RIA METHODS ARE AVAILABLEFOR MONITORING AZT SERUM LEVELS. THEY ARE RELATIVELY SLOW, EXPENSIVE, LABOR INTENSIVE, AND IMPRACTICAL FOR ROUTINE PHARMACOKINETIC STUDIES. IT IS THE OBJECTIVE OF THIS PROGRAM TO DEVELOP AND REFINE A SIMPLE, INEXPENSIVE, AND RELATIVELY RAPID ASSAY FOR AZT IN HUMAN SERUM, URINE, AND OTHER BODY FLUIDS BY MEANS OF A LASER LIGHT-SCATTERING BIOASSAY.

* Information listed above is at the time of submission. *

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