Kumakhow Optics for Clinical Dual-Energy Angiography

Award Information
Agency:
Department of Health and Human Services
Amount:
$50,000.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1993
Phase:
Phase I
Agency Tracking Number:
22309
Solicitation Topic Code:
N/A
Small Business Information
X-ray Optical Systems, Inc.
1400 Washington Avenue, Physic, Albany, NY, 12222
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Qi-Fan Xiao
 (518) 442-5250
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Conventional coronary angiography requires cardiac catheterization to inject an iodine contrast agent. If dual-energy digital subtraction angiography could be performed in clinical practice using intravenous iodine injections, patient risk could be substantially reduced. Additionally, x-ray exposure of the angiographer and other technical personnel during the catheter manipulation/placement would be eliminated. This project would evaluate combining two newly developed capabilities to achieve such a dual-energy angiography system. Science Research Laboratory (SRL) has constructed a compact high-flux characteristic-line x-ray anode source for dual-energy angiography. The effectiveness of this source would be greatly enhanced if the high energy continuum photon flux in the x-ray spectrum could be attenuated. Recent advances in Kumakhov optics utilizing x-ray capillary optics have demonstrated the ability to focus x-ray beams and to filter out high-energy photons. The expected result is a complete system would sequentially provide two very narrow x-ray spectra which bound the iodine K-edge for use in dual-energy digital subfraction angiography. The research performed in Phase I will establish the feasibility of filtering the characteristicline x-ray spectrum with a capillary optic. In Phase II, a Kumakhow x-ray will be constructed and tested with the SRL x-ray source.

* information listed above is at the time of submission.

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