ROTATIONAL ANGIOGRAPHIC DIGITAL IMAGING

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 16709
Amount: $550,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Xre Corp.
300 Foster Street Box 1154, Littleton, MA, 01460
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Grady, John K
 Principal Investigator
 (508) 486-9681
Business Contact
 1 R43 HL46578-01
Phone: () -
Research Institution
N/A
Abstract
INTERVENTIONAL CARDIOLOGY DEPENDS ON THE ACCURATE ASSESSMENT OF THE SEVERITY OF STENOSES, THEIR GEOMETRY AND SPATIAL ORIENTATION. CURRENT THERAPEUTIC DECISIONS ARE BASED UPON INFORMATION GATHERED FROM X-RAY SYSTEMS THAT HAVE NOT CHANGED SIGNIFICANTLY IN OVER TWO DECADES. STANDARD X-RAY IMAGES ARE NOT SUPPLYING THE ANGIOGRAPHER WITH SUFFICIENT INFORMATION NEEDED TO MAKE THERAPEUTIC DECISIONS. COMPUTER-AIDED ASSESSMENT, INTRAVASCULAR ULTRASOUND AND ANGIOSCOPY HAVE INCREASED THE QUALITY OF INFORMATION, BUT ALL HAVE SIGNIFICANT LIMITATIONS. ROTATIONAL ANGIOGRAPHIC DIGITAL IMAGING (PHASE I) IS A PROJECT TO DEFINE THE EXACT PARAMETERS OF AN X-RAY STAND AND IMAGING SYSTEM DESIGNED TO ROTATE AROUND AN OBJECT OR AREA OF CLINICAL INTEREST WHILE RECORDING 2D DIGITAL GREY SCALE AREA IMAGES AT AS RAPID A RATE AS TECHNICALLY ACHIEVABLE, WHILE MAINTAINING A COST-EFFECTIVE APPROACH THAT WILL LEAD TO A COMMERCIALLY VIABLE PRODUCT. THE CLINICAL APPLICATION OF THIS CONCEPT IS TO OBTAIN INFORMATION ON THE SPATIAL DISTRIBUTION OF LESIONS AND VASCULATURE IN REAL TIME WITH A SINGLE INJECTION OF CONTRAST MEDIA. IT IS EXPECTED THAT THIS WILL REPLACE MANY BIPLANE APPLICATIONS, REDUCE RADIATION EXPOSURE TO OPERATORS AND PATIENT, AND REDUCE CONTRAST MEDIA LOAD. THIS IS APPLICABLE FOR ANY DIAGNOSTIC OR INTERVENTIONAL PROCEDURE UTILIZING INTRAVASCULAR CATHETERS, INCLUDING CARDIAC APPLICATIONS.

* information listed above is at the time of submission.

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