Commercialization of Human Visceral Adipocytes

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$961,578.00
Award Year:
2005
Program:
SBIR
Phase:
Phase II
Contract:
2R44DK065323-02A1
Agency Tracking Number:
DK065323
Solicitation Year:
2005
Solicitation Topic Code:
N/A
Solicitation Number:
PHS2005-2
Small Business Information
ZEN-BIO, INC.
P.O. Box 13888, 3200 Chapel Hill-Nelson Blvd., Rtp, NC, 27709
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 YOLANDA LEACURRIE
 (919) 547-0692
 RENEE@ZEN-BIO.COM
Business Contact
 PETER PIERACCINI
Phone: (919) 547-0692
Email: PETER@ZEN-BIO.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): The US is experiencing an epidemic rise in obesity and related co-morbidities such as type II diabetes. Epidemiological studies demonstrate that these co-morbidities are specifically correlated with visceral (intra-abdominal) fat deposition. To elucidate this association, a fully characterized and performance tested cultured human adipocyte cell system must be made available to researchers. The goal of the proposed work is to develop a commercially accessible, novel, well characterized cultured human visceral adipocyte cell system. Preliminary data indicate visceral adipocytes are distinct from subcutaneous adipocytes, requiring individualized culturing and assaying techniques. Phase II has three specific aims. I. Establish a protocol for differentiation of visceral preadipocytes into adipocytes. II. Develop a suite of assays necessary to provide quality control tests for the cultured cells. The assays will also be offered as a commercial contract research service utilizing the visceral cell system. III. Perform expression profiling of primary and cultured visceral adipocytes and preadipocytes in order to validate the cultured cell system. The completion of the research will result in a commercially accessible, performance tested, fully validated cultured human visceral adipocyte cell system. Availability of this system will open the door for large scale screening in cultured human visceral cells, provide a better understanding of the roles visceral adipose plays in disease development and provide a faster and less expensive path to drug development.

* information listed above is at the time of submission.

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