SALIVA AND CERVICAL MUCUS MONITOR TO DEFINE OVULATION

Award Information
Agency:
Department of Health and Human Services
Amount:
$379,000.00
Program:
SBIR
Contract:
N/A
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
1986
Phase:
Phase II
Agency Tracking Number:
3131
Solicitation Topic Code:
N/A
Small Business Information
Zetek, Inc.
794 Ventura Street, Aurora, CO, 80011
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 Ranjit S. Fernando
 Principal Investigator
 (303) 343-2122
Business Contact
Phone: () -
Research Institution
N/A
Abstract
PRELIMINARY STUDIES PERFORMED BY APPLICANT IN COOPERATION WITH DR. GEORGE BETZ, UNIVERSITY OF COLORADO HEALTH SCIENCES CENTER, INDICATE THAT THE FERTILE PERIOD IN WOMEN CAN BE DEFINED BY MONITORING ELECTRICAL CHARACTERISTICS OF SALIVA AND CERVICAL MUCUS. PREVIOUS INVESTIGATORS HAVE SHOWN THAT ELECTROLYTE CONSTITUENTS OF THESE FLUIDS CHANGE CYCLICALLY IN RELATION TO CONCENTRATIONS OF REPRODUCTIVE HORMONES IN WOMEN. MORE DATA ARE NEEDED TO VALIDATE THE METHOD. A PROBABLE PHYSIOLOGICAL RATIONALE FOR OBSERVED CHANGES IN SALIVARY AND VAGINAL IONIC CONTENT AND THEIR RELATIONSHIP TO IN THIS STUDY, FIFTY WOMEN WILL RECORD DAILY MEASUREMENTS USING A SPECIALLY DESIGNED INSTRUMENT. BASAL BODY TEMPERATURE (BBT) WILL BE RECORDED, BUT WILL NOT BE USED TO DEFINE THE TIME OF OVULATION. OVULATION WILL BE DIAGNOSED BY LUTEINIZING HORMONE (LH) ASSAY AND, WHERE APPROPRIATE, BY ULTRASOUND SCAN AS WELL. STATISTICAL EVALUATION OF THE CORRELATION OF THE ELECTRICAL MEASUREMENTS WITH OVULATION WILL BE PERFORMED. IF SUCCESSFUL, THIS RESEARCH WILL RESULT IN A VERY USEFUL TOOL FOR THE MANAGEMENT OF INFERTILITY IN THE NEAR FUTURE. LATER, IT IS EXPECTED THAT THE INSTRUMENT WILL ALSO BE USED TO AID NATURAL FAMILY PLANNING.

* information listed above is at the time of submission.

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