Bioprocess for Xylitol from Hemicellulose

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-FG02-07ER84793
Agency Tracking Number: 83038
Amount: $748,800.00
Phase: Phase II
Program: SBIR
Awards Year: 2008
Solicitation Year: 2007
Solicitation Topic Code: 01
Solicitation Number: DE-PS02-06ER06-30
Small Business Information
2201 W. Campbell Park Drive, Ste 39, Chicago, IL, 60612
DUNS: 126677041
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Mike Racine
 (309) 681-6188
Business Contact
 Gina Berardesco
Title: Dr
Phone: (312) 997-2150
Research Institution
When ethanol is produced from corn, only the starch is transformed, and a significant amount of byproducts is produced. If these byproducts, which are rich in sugars, could be made into a valuable product, the cost-effectiveness of ethanol production will be enhanced. One such potential product is xylitol, a five-carbon polyalcohol that has gained acceptance as a natural food sweetener that can replace sucrose on a weight-for-weight basis. Although xylitol is in high demand by the food ingredient and confectionary industries, its use currently is constrained by the limited supply of raw materials. This project will develop a bioprocess to transform waste sugars into xylitol, thereby improving the economics of ethanol production. In Phase I, bacterial host strains were developed for the transformation of these waste sugars. In addition, the various feedstocks that would feed the bioprocess were evaluated, several prototype bioconversion systems were assembled and tested, and some preliminary metabolic engineering was performed to demonstrate feasibility. Phase II will involve further metabolic engineering, fine-tuning of the fermentation process, and scaling-up the process to commercial levels. Commercial Applications and other Benefits as described by the awardee: The new bioprocess should significantly reduce the cost of commercial xylitol production, free xylitol production from the current raw-material-availability constraints, and have a positive impact on the economics of fuel ethanol production. Moreover, domestic firms would be able to produce xylitol more cheaply, thereby avoiding the need to relocate manufacturing facilities to Southeast Asia. Finally, the new bioprocess should be inherently cleaner and safer than the existing hydrogenation process for xylitol.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government