Z-Tag for Measuring Cardiac Contractility and Cardiac Rhythmicity

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HL088809-01
Agency Tracking Number: HL088809
Amount: $153,994.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
58 Edgewood Avenue, 1st Floor, Room 122, ATLANTA, GA, 30303
DUNS: 028796170
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 (404) 523-7309
Business Contact
Phone: (404) 523-7309
Email: nina@zygogen.com
Research Institution
DESCRIPTION (provided by applicant): A major concern regarding drugs in development is cardiac toxicity. Commonly, drugs in development can cause changes to cardiac contractility, the force with which the heart beats, and cardiac rhythmicity, resulting in toxic side effects. The purpose of this Phase 1 proposal is to develop zebrafish assays for measuring drug-induced changes in cardiac contractility and cardiac rhythmicity. These assays will be developed using a transgenic zebrafish line expressing a green fluorescent reporter protein specifically in the heart. Methods of assessing contractility and rhythmicity in zebrafish will be developed. Drugs that are known to cause changes to cardiac contractility and rhythmicity in humans will be tested using these zebrafish in order to validate the assay. Development of these assays will allow high-throughput, in vivo testing of drugs in development for cardiac toxicity.

* Information listed above is at the time of submission. *

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