Z-Tag for Measuring Cardiac Contractility and Cardiac Rhythmicity

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$153,994.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL088809-01
Agency Tracking Number:
HL088809
Solicitation Year:
2007
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ZYGOGEN, LLC
58 Edgewood Avenue, 1st Floor, Room 122, ATLANTA, GA, 30303
Hubzone Owned:
N
Socially and Economically Disadvantaged:
Y
Woman Owned:
Y
Duns:
028796170
Principal Investigator:
PETER EIMON
(404) 523-7309
peter@zygogen.com
Business Contact:
NINA SAWCXUK
(404) 523-7309
nina@zygogen.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): A major concern regarding drugs in development is cardiac toxicity. Commonly, drugs in development can cause changes to cardiac contractility, the force with which the heart beats, and cardiac rhythmicity, resulting in toxic side effects. The purpose of this Phase 1 proposal is to develop zebrafish assays for measuring drug-induced changes in cardiac contractility and cardiac rhythmicity. These assays will be developed using a transgenic zebrafish line expressing a green fluorescent reporter protein specifically in the heart. Methods of assessing contractility and rhythmicity in zebrafish will be developed. Drugs that are known to cause changes to cardiac contractility and rhythmicity in humans will be tested using these zebrafish in order to validate the assay. Development of these assays will allow high-throughput, in vivo testing of drugs in development for cardiac toxicity.

* information listed above is at the time of submission.

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