Displacement Chromatography of Coagulation Proteins

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 22354
Amount: $49,680.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Zymequest, Inc.
Science Laboratory Building, R, Ogden, UT, 84408
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Anthony R. Torres
 (801) 626-7990
Business Contact
Phone: () -
Research Institution
N/A
Abstract
It is proposed that coagulation factor proteins (VII, VIII, and IX) be purified by high resolution displacement chromatography directly from human plasma. Preliminary data shows that broad affinity displacers are effective in substantially purifying these proteins from each other and other plasma proteins. The displacer affinities that are effective in spacing these proteins will be determined and used to synthesize custom narrow-range displacers for large scale purifications. All purifications will be assayed with factor deficient substrate plasma, gel electrophoresis and immunoblots.

* information listed above is at the time of submission.

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