Displacement Chromatography of Coagulation Proteins

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,680.00
Award Year:
1993
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
22354
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Zymequest, Inc.
Science Laboratory Building, R, Ogden, UT, 84408
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Anthony R. Torres
(801) 626-7990
Business Contact:
() -
Research Institution:
n/a
Abstract
It is proposed that coagulation factor proteins (VII, VIII, and IX) be purified by high resolution displacement chromatography directly from human plasma. Preliminary data shows that broad affinity displacers are effective in substantially purifying these proteins from each other and other plasma proteins. The displacer affinities that are effective in spacing these proteins will be determined and used to synthesize custom narrow-range displacers for large scale purifications. All purifications will be assayed with factor deficient substrate plasma, gel electrophoresis and immunoblots.

* information listed above is at the time of submission.

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