DECONTAMINATION OF PLATELET CONCENTRATES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7322
Agency Tracking Number:
7322
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2220 Livington St, Oakland, CA, 94606
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GARY P WIESEHAHN PHD
(515) 262-9341
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OVERALL OBJECTIVE OF THE RESEARCH IS TO DEFINE A SYSTEM FOR DECONTAMINATING PLATELET CONCENTRATES. PRESENT SCREENING OF DONATED BLOOD DOES NOT DETECT ALL POTENTIALLY INFECTIOUS CONTAMINANTS. THEREFORE, IT IS IMPORTANT TO FINDA MEANS OF RENDERING BLOOD PRODUCTS NONSPECIFICALLY NONINFECTIOUS TO REDUCE THE RISK OF VIRAL INFECTION AND BACTERIAL SEPSIS ASSOCIATED WITH THERAPEUTIC USE OF PLATELETCONCENTRATES. DIAMOND SCIENTIFIC COMPANY PROPOSES TO DEMONSTRATE THE ABILITY TO INACTIVATE AN ANIMAL-VIRUS MODEL IN PLATELET CONCENTRATES. THE EFFECTS OF THE INACTIVATION TREATMENT ON THE FOLLOWING WILL BE EXAMINED: (1) GROSS PLATELET MORPHOLOGY, BY MEASURING PLATELET COUNT AS A FUNCTION OF INACTIVATION TIME; (2) RESPONSE OF PLATELETS TO AGGREGATING AGENTS; AND (3) PLATELET ACTIVATION BY FLUORESCENT ANTIBODY ASSAY. THIS RESEARCH HAS THE POTENTIAL TO BE COMMERCIALLY USEFUL IN SAFEGUARDING THE ESTIMATED 5 TO 7 MILLION UNITS OF PLATELETS TRANSFUSED ANNUALLY.

* information listed above is at the time of submission.

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