PHASE I RESEARCH WILL DEMONSTRATE THE TECHNICAL MERIT AND FEASIBILITY OF USING COMPUTER-ASSISTED ANALYSIS OF RED BLOODCELL VOLUME DISTRIBUTIONS IN THE DIAGNOSTIC EVALUATION OF ANEMIA.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4866
Agency Tracking Number:
4866
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1005 Natl City Bank Bldg, 629 Euclid Avenue, Cleveland, OH, 44114
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GARY A REGULA
PRINCIPAL INVESTIGATOR
(216) 589-5891
Business Contact:
() -
Research Institute:
n/a
Abstract
PHASE I RESEARCH WILL DEMONSTRATE THE TECHNICAL MERIT AND FEASIBILITY OF USING COMPUTER-ASSISTED ANALYSIS OF RED BLOODCELL VOLUME DISTRIBUTIONS IN THE DIAGNOSTIC EVALUATION OF ANEMIA. CURRENT AUTOMATED HEMATOLOGY ANALYZERS MEASURE THE VOLUME OF EACH RED CELL, PROVIDING THE RED CELL VOLUME DISTRIBUTION. PROCEDURES DEVELOPED HAVE BEEN ADOPTED BY THEEXPERT PANEL ON CYTOMETRY OF THE INTERNATIONAL COMMITTEE FORSTANDARDIZATION IN HEMATOLOGY (ICSH) FOR INCLUSION AS AN ICSH REFERENCE METHOD IN THEIR RECOMMENDATIONS FOR THE STANDARDIZATION OF CELL SIZE DISTRIBUTION ANALYSIS. THE MAJOR GOAL OF THE PROPOSED PHASE I PROJECT IS TO ADAPT THESEPROCEDURES FOR ROUTINE USE WITH COMMERCIALLY AVAILABLE AUTOMATED HEMATOLOGY ANALYZERS OPERATING IN A CLINICAL LABORATORY. THE CONSULTANTS' COMPUTER PROGRAMS WILL BE ADAPTED FOR USE WITH A MICROCOMPUTER SYSTEM TO PRODUCE STATISTICAL AND GRAPHICAL ANALYSES OF RED CELL VOLUME DATA AND A SYNOPSIS OF POTENTIAL DIAGNOSTIC INTERPRETATIONS. A COMPUTERIZED STANDARD PROTOCOL FOR THE ANALYSIS OF RED CELL VOLUME DISTRIBUTIONS IS URGENTLY NEEDED TO MAKE GENERALLY AVAILABLE THE NEW DIAGNOSTIC INFORMATION DERIVED FROM CURRENT ELECTRONIC PARTICLE COUNTERS. IT WOULD PROVIDE A CLINICALLY USEFUL, COST-EFFECTIVE APPROACH TO IMPROVING THE EVALUATION AND MANAGEMENT OF ANEMIA.

* information listed above is at the time of submission.

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