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Bioimpedance Control of Ultrafiltration on Hemodialysis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 DK49892-01,
Agency Tracking Number: 29393
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2701-B Kent Avenue
West Lafayette, IN 47906
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Stephen Ash
 () -
Business Contact
Phone: () -
Research Institution

We will apply thoracic electric bioimpedance monitoring by external electrodes (TEB) to those patieunstable on hemodialysis and find a primary cardiovascular parameter which predicts the onset of symOur expectation is that percent fall in cardiac output will be the primary indicator, but we will alcardiovascular parameters, machine-generated ultrafiltration data, and SO2 and hematocrit (by Crit-Lthat there are no better predictors of symptomatic hypotension. We will define a "stop-UF" algorithmultrafiltration rate before symptomatic hypotension and clinically test this in Phase II. Also in Phclinically test a "dry weight" algorithm which monitors cardiovascular parameters and receives usersymptoms and clinical findings to automatically determine dry weight of all hemodialysis patients.

* Information listed above is at the time of submission. *

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