NONINVASIVE IMMUNODETECTION OF ECTOPIC PREGNANCY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
13747
Agency Tracking Number:
13747
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
1240 Elko Dr, Sunnyvale, CA, 94089
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
David C Casal
(408) 745-0975
Business Contact:
() -
Research Institution:
n/a
Abstract
THIS PROJECT WILL DEVELOP A NEW DIAGNOSTIC TEST TO SUBSTANTIALLY IMPROVE THE DEFINITIVE DIAGNOSIS OF ECTOPIC PREGNANCY (EP). THIS NEW TEST WOULD COMPLEMENT SERIAL QUANTITATIVE BETA-HCG AND ULTRASOUND TESTING, CURRENTLY USEDFOR DIAGNOSING EP, AND PROVIDE EARLIER AND MORE ACCURATE DIAGNOSIS OF THIS POTENTIALLY FATAL CONDITION. THE NEW TEST IS BASED ON A RECENTLY DISCOVERED MARKER, A UNIQUE PREGNANCY-RELATED PROTEIN (PRP) SECRETED BY THE PROLIFERATIVE TROPHOBLAST DURING THE EARLY STAGES OF PREGNANCY. PRP CAN BE IMMUNOLOGICALLY DETECTED BY A MONOCLONAL ANTIBODY, KNOWN AS A137, DEVELOPED AT ASPEN DIAGNOSTICS CORPORATION. PRP IS PRESENT IN THE CERVICAL MUCOUS OF PREGNANT WOMEN WITH INTRAUTERINE IMPLANTATION BUT APPEARS TO BE ABSENT IN WOMEN WITH EXTRAUTERINE IMPLANTATION. THE ABILITY TO PREDICT THE LOCATION OF A PREGNANCY COULD PROVIDE EARLIER, NONINVASIVE DIAGNOSIS OF EP, BYPASSING COSTLY ULTRASOUND OR INVASIVE DIAGNOSTIC LAPAROSCOPY. FURTHERMORE, RAPID AND ACCURATE DIAGNOSIS AND TREATMENT COULD LOWER THE RATE OF TUBAL RUPTURE, THEREBY LOWERING MORBIDITY AND MORTALITY ASSOCIATED WITH EP. EARLY DIAGNOSIS AND TREATMENT OF EP MAY ALSO IMPROVE FUTURE FERTILITY OF THE AFFECTED PATIENT.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government