CONTROLLED NUCLEATION OF PROTEIN CRYSTAL GROWTH

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$415,526.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
17131
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Crystal Research
1441 Sunnyside Terr, San Pedro, CA, 90732
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
TO SUPPORT THE GROWTH OF PROTEIN CRYSTALS IN MICRO-GRAVITY, THIS PROJECT WILL IMPROVE THE CONTROL OF NUCLEATION BY THE USE OF EPITAXIAL SUBSTRATES, INSTEAD OF SEED CRYSTALS OR SPONTANEOUS NUCLEATION, TO GREATLY SIMPLIFY FLIGHT APPARATUS AND INCREASE EXPERIMENT RELIABILITY. SPECIFICALLY, THIS PROJECT WILL DEVELOP, EXPERIMENTALLY VERIFY, AND APPLY A COMPUTER PROGRAM FOR RAPIDLY FINDING ALL POSSIBLE EXPITAXIAL SUBSTRATES FOR ANY GIVEN PROTEIN CRYSTAL. PHASE I TASKS WILL INCLUDE ESTABLISHMENT OF THE VALIDITY OF THE SEARCH ALGORITHM, DEVELOPMENT AND TESTING OF A PRELIMINARY VERSION OF THE SEARCH PROGRAM AND PREDICTIONS OF NEW CASES, AND EXPERIMENTAL VERIFICATION OF THESE PREDICTIONS. THE ULTIMATE GOAL IS TO PROVIDE EPITAXIAL SUBSTRATES FOR ALL MICROGRAVITY PROTEIN-CRYSTAL GROWTH EXPERIMENTS. TO SUPPORT THE GROWTH OF PROTEIN CRYSTALS IN MICRO-GRAVITY, THIS PROJECT WILL IMPROVE THE CONTROL OF NUCLEATION BY THE USE OF EPITAXIAL SUBSTRATES, INSTEAD OF SEED CRYSTALS OR SPONTANEOUS NUCLEATION, TO GREATLY SIMPLIFY FLIGHT APPARATUS AND INCREASE EXPERIMENT RELIABILITY. SPECIFICALLY, THIS PROJECT WILL DEVELOP, EXPERIMENTALLY VERIFY, AND APPLY A COMPUTER PROGRAM FOR RAPIDLY FINDING ALL POSSIBLE EXPITAXIAL SUBSTRATES FOR ANY GIVEN PROTEIN CRYSTAL. PHASE I TASKS WILL INCLUDE ESTABLISHMENT OF THE VALIDITY OF THE SEARCH ALGORITHM, DEVELOPMENT AND TESTING OF A PRELIMINARY VERSION OF THE SEARCH PROGRAM AND PREDICTIONS OF NEW CASES, AND EXPERIMENTAL VERIFICATION OF THESE PREDICTIONS. THE ULTIMATE GOAL IS TO PROVIDE EPITAXIAL SUBSTRATES FOR ALL MICROGRAVITY PROTEIN-CRYSTAL GROWTH EXPERIMENTS.

* information listed above is at the time of submission.

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