Biomarker Based Neural Protectants
Department of Defense
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303 Bear Hill Road, Waltham, MA, 02451
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AbstractAs long as organophosphates are one of the most probable chemical warfare agents or agents of choice in a terrorist attack, protection of military personnel against these compounds is an important component of sustained troop performance, confidence, and morale. The latest advances in understanding the mechanisms involved in the toxicity of organophosphates include identification of several significant biomarkers following exposure to organophosphates. The proposed program focuses on developing methods to study the signaling pathways generated by these molecular and genetic events and to use them for the development of novel, highly effective, neural protectants against organophosphates.
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