METHODS TO PREDICT PROTEIN BINDING SITES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$44,755.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
13822
Agency Tracking Number:
13822
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
10463 Austin Dr #k, Spring Valley, CA, 92078
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Terence K Brunck
(619) 660-9035
Business Contact:
() -
Research Institute:
n/a
Abstract
THIS RESEARCH ADDRESSES ONE OF THE MOST IMPORTANT PROBLEMS IN PROTEIN CHEMISTRY, THAT OF PREDICTING BINDING SITES ON THE SURFACES OF BILOGICALLY SIGNIFICANT PROTEINS. THE LONG-TERM GOAL OF THIS WORK IS TO USE THE ABILITY TO IDENTIFY BINDING SITES FROM STRUCTURAL INFORMATION ALONE TO DESIGN NEW PHARMACEUTICAL MOLECULES WITH IMPROVED PROPERTIES. SPECIFICALLY, THE OBJECTIVES OF THIS PROJECT ARE TO DEVELOP STATISTICAL ANALYSES OF THE ENVIRONMENTS OF AMINO ACIDS ON PROTEIN SURFACES, TO IDENTIFY AND QUANTITATE SURFACE ABNORMALITIES, AND TO CORRELATE THESE WITH EXPERIMENTALLY DETERMINED BINDING SITES. IF SUCCESSFUL, THIS WILL REPRESENT THE FIRST COMPREHENSIVE METHOD TO PREDICT BINDING SITES USING ONLY THE THREE-DIMENSIONAL STRUCTURE OF A PROTEIN. FOLLOW-ON RESEARCH WILL USE THESE METHODS AND APPROACHES IN COLLABORATIONS WITH ESTABLISHED PHARMACEUTICAL COMPANIES TO DESIGN NEW PROTEIN AND PEPTIDE DRUGS WITH IMPROVED SPECIFICITES, STABILITIES, AND IMMUNOLOGICAL PROPERTIES.

* information listed above is at the time of submission.

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