A NOVEL SCREEN FOR INHIBITORS OF FUNGAL GPI-ANCHORING

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI048337-01A2
Agency Tracking Number: AI048337
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
MYCOLOGICS, INC.
MYCOLOGICS, INC., 12635 E MONTVIEW BLVD, AURORA, CO, 80010
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 CLAUDE SELITRENNIKOFF
 (303) 315-8647
 CLAUDE.SELITRENNIKOFF@UCHSC.EDU
Business Contact
 CLAUDE SELITRENNIKOFF
Phone: (720) 859-4190
Email: CLAUDE.SELITRENNIKOFF@UCHSC.EDU
Research Institution
N/A
Abstract
Perhaps the most striking difference between fungal cells and human cells is that fungal cells are encased in a wall that protects them from a hostile external environment. The cell wall plays a dynamic role in all aspects of fungal physiology. The fact that human cells lack a cell wall and the underlying biosynthetic and regulatory machinery to make the wall, suggests that drugs targeting cell-wall synthesis and assembly will be safe and specific antifungals. Current treatments include Amphotericin B and a variety of azoles that inhibit membrane-sterol biosynthesis. Unfortunately, Amphotericin B is toxic to humans and clinical resistance to azoles is increasing. These observations underscore the clear need for new antifungals. In this Phase I SBIR application, we propose to develop a novel screen that targets an essential step in fungal cell-wall assembly, namely, the extracellular anchorage of GPI-class mannoproteins. This will be accomplished in two specific aims: 1). Development of a screen to detect inhibitors of GPI-mannoprotein anchoring into the cell wall; 2). Screening of extracts for inhibitors using the assay developed in Aim One.

* information listed above is at the time of submission.

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