Antimicrobial Bone Graft Substitute

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0062
Agency Tracking Number: A043-190-1151
Amount: $69,938.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2004
Solicitation Topic Code: A04-190
Solicitation Number: 2004.3
Small Business Information
NANOTHERAPEUTICS, INC.
12085 Research Dr Ste N, Suite N, Alachua, FL, 32615
DUNS: 073438462
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 James Talton
 President and CEO
 (386) 462-9663
 jtalt@nanotherapeutics.com
Business Contact
 James Talton
Title: President and CEO
Phone: (386) 462-9663
Email: jtalt@nanotherapeutics.com
Research Institution
N/A
Abstract
In this Phase I SBIR project, Nanotherapeutics proposes to utilize its proprietary particle delivery systems to develop an injectable bone paste formulation incorporating an anti-microbial (PHMB) as a bone graft substitute. A solution-based system, GraftonT (Osteotech) and, recently, a dry osteconductive powder available for reconstitution, OSTEOFILT, became available as superior bone grafts, but each with drawbacks. A new composition incorporating gelatin-coated particles, NanopasteTM (produced by Nanotherapeutics, Inc., patent pending), which has excellent syringability, has proven to be osteconductive in animal studies and is currently licensed (undisclosed). This composition is particulary suitable for incorporation of additional anti-microbial materials, such as PHMB, which may be simply physically mixed in or encapsulated to produce slow-release over days. Using its proprietary powder processing technologies, sustained-release PHMB / NanopasteTM formulations will be tested with significant advantages over standard bone graft materials. In this six month Phase I project, preparation of PHMB / NanopasteTM formulations and in vitro characterization and release will be performed, and preparation for in vivo animal studies to test the efficacy in rodents will be conducted.

* information listed above is at the time of submission.

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