PC-NSAIDs: Gastrointestinal-safe and potent anti-inflammatory drugs

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-08-C-0025
Agency Tracking Number: A072-142-0602
Amount: $117,392.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: A07-142
Solicitation Number: 2007.2
Small Business Information
8285 EL RIO, SUITE 130, HOUSTON, TX, 77054
DUNS: 140243572
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Upendra Marathi
 Senior Vice President
 (713) 842-1249
Business Contact
 Ron Zimmerman
Title: President
Phone: (713) 842-1249
Email: ron.zimmerman@plxpharma.com
Research Institution
Contrasting in vitro and in vivo systems will be used to evaluate the anti-inflammatory/analgesic activity and side-effects of a family of phosphatidylcholine (PC) – associated NSAIDs. Previous studies indicate that PC-NSAIDs have equivalent and/or enhanced therapeutic activity while GI ulceration/bleeding is remarkably reduced. Dr. Susan Carlton’s lab will measure the effect of our test NSAIDs (PC-NSAID vs unmodified NSAIDs) on calcium signaling of rodent dorsal root ganglia cells in response inflammatory mediators. Her lab also will electrophysiologically measure the effect of test NSAIDs on nociceptive C-fiber activity of a rodent skin-nerve preparation. Dr. Catherine Ambrose will investigate the effect of the test NSAIDs on growth/apoptosis of human osteoblasts in culture. During the Option period, Dr. Lenard Lichtenberger’s lab will utilize a rodent model of adjuvant-induced joint inflammation that provides information on the anti-inflammatory/analgesic activity of the test NSAIDs and their ability to induce GI ulceration/bleeding. The synovial fluid eicosanoids will be measured by HPLC/MS. Dr. Carlton also will evaluate the anti-inflammatory/analgesic activity of PC-NSAIDs using a rodent hindlimb incision model. In Phase II we plan to expand our in vivo evaluation of PC-NSAIDs using an array of rodent model systems available in the labs of the Co-Investigators.

* information listed above is at the time of submission.

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government