Improved Protease Inhibitor Therapy for AIDS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 CA68999-01,
Agency Tracking Number:
29271
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Sts Duotek, Inc.
336 Summit Point Drive, Henrietta, NY, 14467
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Michael Violante
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
Our company will formulate a protease inhibitor, KNI-272, to improve bioavailability following oraladministration. This will be accomplished using patented technology to convert this nearly water-insspherical, amorphous, uniformly-sized submicron particles suspended in a biocompatible aqueous mediuhas been used to produce formulations for anti-cancer and antimicrobial therapy with improved oral bformulation of KNI-272 will be subjected to preliminary bioavailability evaluations in mice to demonPhase II objectives will focus on preclinical efficacy and toxicity studies following oral administrbenefits of intravenous administration. In Phase III, clinical trials will be carried out.

* information listed above is at the time of submission.

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