Handheld CB Aptamer Based MEMS Fluorescence Point Detection Sensor

Award Information
Agency: Department of Defense
Branch: Navy
Contract: N00014-04-C-0120
Agency Tracking Number: N022-0638
Amount: $492,999.00
Phase: Phase II
Program: SBIR
Awards Year: 2004
Solicitation Year: 2002
Solicitation Topic Code: N02-207/1
Solicitation Number: 2002.2
Small Business Information
101 West Sixth Street Suite 200, Austin, TX, 78701
DUNS: 001021042
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Austin Sequeira
 CEO
 (512) 479-7732
 sequeira@spec.com
Business Contact
 Jean Lang
Title: Contracts Director
Phone: (512) 479-7732
Email: lang@spec.com
Research Institution
N/A
Abstract
OmniSite Biodiagnostics, Inc. and its parent company, Systems and Processes Engineering Corporation (SPEC), have extensive experience in both microfluidic, micromechanical (MEMS) and Fluorescence detection technologies. OmniSite proposes to design and prototype a compact, handheld and low power MEMS-Fluorescence sensor capable of simultaneously detecting different biowarfare agents in aqueous samples. OmniSite, in collaboration with Dr. Andrew Ellington's laboratory at UT Austin and Accacia International, will develop DNA Aptamer coated magnetic microbead based fluorescence assays to be analyzed in a prototype MEMS cartridge and ultimately read on a Fluorescence Cartridge Reader. DNA Aptamers are short oligonucleotides that act like antibodies by binding any target against which they are raised with very high affinity and specificity. Aptamers are generated by a process called SELEX (Systematic Evolution of Ligands by EXponential enrichment) consisting of alternating iterations of affinity selection (from a random DNA library allowed to interact with the immobilized target), washing and PCR amplification of selected DNA sequences that bind the target.

* Information listed above is at the time of submission. *

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