INSTRUMENTATION FOR MULTI-ISOTOPE BETA-GAMMA DETECTION

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
8146
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Applied Research Corp
8201 Corporate Dr, Suite 920, Landover, MD, 20785
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
APPLIED RESEARCH CORPORATION PROPOSES THE DEVELOPMENT OF A NOVEL TECHNIQUE FOR CONSIDERABLY INCREASING THE SPEED AND EFFICIENCY OF DNA SEQUENCING. THIS TECHNIQUE IS BASED ON MULTIPLE ISOTOPIC DETERMINATION USING B( )/( ) COINCIDENCE AND CAN BE EXTENDED TO ANALYZE THE OUTPUT OF OTHER FRACTIONATION PROCESSES, E.G., COLUMN CHROMATOGRAPHY. THE PROPOSED SYSTEM: IS FULLY AUTOMATED; PERMITS MULTI-ISOTOP IMAGING; PROVIDES SIZE AND SPATIAL RESOLUTION COMPARABLE TO NUCLEAR EMULSIONS;AND AFFORDS QUANTUM DETECTION EFFICIENCY ORDERS OF MAGNITUDEBETTER THAN "AUTORADIOGRAPHY". THE USE OF 15 ISOTOPES OF BROMINE/IODINH PROMISE ORDERS OF MMAGNITUDE ACCELERATION OF ANALYTICAL PROCEDURES USED NOT ONLY IN DNA-SEQUENCING, BUT ALSO IN HUNTING FOR GENES RESPONSIBLE FOR GENETIC DISEASE.

* information listed above is at the time of submission.

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