SBIR Phase I: Inexpensive and effecient system for signal amplification

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$149,953.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
1113377
Award Id:
n/a
Agency Tracking Number:
1113377
Solicitation Year:
2010
Solicitation Topic Code:
BC
Solicitation Number:
n/a
Small Business Information
1202 Ann Street, Madison, WI, 53713-2410
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
144579641
Principal Investigator:
AlexeyZdanovsky
(608) 661-0861
alexeyzd@tds.net
Business Contact:
AlexeyZdanovsky
(608) 661-0861
alexeyzd@tds.net
Research Institute:
Stub




Abstract
This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a signal amplification system that, while being inexpensive and simple to use, can be combined with antibodies or other probe molecules, and can increase detection limits of conventional ELISAs by 100- to 1000-fold, or even higher. To prove the concept, it is proposed to apply this system to rabbit antibodies and demonstrate that, in combination with rabbit antibodies raised against botulinum neurotoxin A, it will be able to provide sensitivity of detection similar to that of immuno-PCR, but at a fraction of the cost. The broader impact/commercial potential of this research is expected in the areas of basic research, biodefense, and medicine. This system will allow very sensitive and inexpensive detection of antigens of choice. For those involved in basic research, the proposed immunoassay will allow a significantly more detailed analysis of biological processes, possibly even opening the doors to monitoring those processes and molecules previously undetectable. In biodefense and medical diagnostics, increased sensitivity will mean an increased security by allowing earlier detection of harmful pathogens, as well as pathological change.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government