SBIR Phase II: Vibrational CD Microscopy for Characterizing Supramolecular Bio-Chirality

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$431,690.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
1058581
Award Id:
n/a
Agency Tracking Number:
1058581
Solicitation Year:
2011
Solicitation Topic Code:
Phase II
Solicitation Number:
n/a
Small Business Information
17546 Bee Line Hwy, JUPITER, FL, 33458-6433
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
117950563
Principal Investigator:
Rina Dukor
(561) 625-0133
rkdukor@aol.com
Business Contact:
Rina Dukor
PhD
(561) 625-0133
rkdukor@aol.com
Research Institution:
Stub




Abstract
This Small Business Innovation Research (SBIR) Phase II project is focused on the creation of a new revolutionary imaging instrumentation that combines vibrational circular dichroism (VCD) spectroscopy with infrared (IR) spectral microscopy. VCD microscopy represents a new class of spectroscopic imaging diagnostic capable of measuring VCD images with millimeter to sub-millimeter spatial resolution. The recent discovery that long-range structural chirality in protein fibrils is characterized by unusually large and distinctive VCD spectra provides the backdrop for this project. None of the currently available techniques can characterize the fibrillation pathway or the final fibril state with the same ease and detail as VCD. VCD microscopy can be thought of as circular polarization contrast microscopy that is sensitive to long-range chiral order in localized regions of biological samples. The broader impacts of this research are studies of the supramolecular chirality of fibrils. This product is not a small improvement of an existing technology but a distinctly new method of studying long-range biochirality that is more sensitive, provides more detail, and is easy and fast to use. A secondary, higher-impact long-term impact will be clinical research laboratories where this innovation can be used for the detection and characterization of amyloids in vivo, i.e. for tissue biopsies, rapid detection of amyloids and drug screening.

* information listed above is at the time of submission.

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