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Electrical System for Rapid Bacterial Cultures

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AI096572-01
Agency Tracking Number: R43AI096572
Amount: $114,830.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIAID
Solicitation Number: PA10-050
Solicitation Year: 2011
Award Year: 2011
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
7200 Highway 150
Greenville, IN -
United States
DUNS: 621970383
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (812) 923-9591
Business Contact
Phone: (812) 923-9591
Research Institution

DESCRIPTION (provided by applicant): The broad, long-term objective of the proposed project Electrical System for Rapid Bacterial Cultures is to develop an automated electrical impedance analyzer for measuring bacterial growth in contaminated blood. Thepurpose of the System is to hasten the time to diagnose sepsis from 1-2 days down to a few hours. The specific aims of the project are to (1) build an agitated culture system that can be sampled automatically every 10-15 minutes, (2) build a dedicated electronics package that performs the desired electrical (impedance) measurements, and (3) combine these devices to test the System's ability to automatically and rapidly measure bacterial growth in blood samples. The proposed System will accommodate only oneculture at a time, whereas clinical laboratories will require that 10's of samples be analyzed simultaneously; therefore, the final specific aim will be to (4) prepare a design for a clinical version of the System capable of simultaneously measuring bacterial growth in multiple blood sample cultures. The outcome of this research is expected to be a drastically reduced time (factor of 4 - 10) required to identify sepsis and sepsis organisms in the clinical laboratory thereby averting hundreds of hospital-based deaths annually. PUBLIC HEALTH RELEVANCE: Hospitalized patients often fear an incident of sepsis (bacterial infection of the blood), which is too frequently fatal. A significant factor in sepsis recovery is the rate at which the disease state canbe properly identified. Techshot and colleagues at the University of Missouri have proposed an electrical measurement device that can detect bacterial growth in blood in a few hours, rather than the 1 or 2 days currently (which is sometimes too late).

* Information listed above is at the time of submission. *

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