Phage Display Peptide Probes for Imaging Early Response to Cancer Therapy

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$236,000.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA150286-01A1
Award Id:
n/a
Agency Tracking Number:
R43CA150286
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
PA10-050
Small Business Information
11171 BUBB RD, CUPERTINO, CA, 95014-4956
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
827596029
Principal Investigator:
JENNY WU
(415) 723-2753
jennywu@acaduceuspharma.com
Business Contact:
JENNY WU
(408) 306-5635
jennywu@acaduceuspharma.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): The ultimate goal of this SBIR proposal is to develop novel molecular imaging markers for monitoring tumor early response and efficacy to anti-angiogenic treatment regimens. Anti-angiogenic therapy represents an exciting advance in the management of cancer. Targeting of the vasculature has been shown to benefit patients with several types of malignancies. Hundreds of molecules with anti-angiogenic activity in preclinical models have been reported, and many of them have entered clinical testing in oncology. It is predicted that Avastin will be the top one drug in 2014 with a projected 8.9 billion in sales. Although many patients benefit from anti-angiogenic therapies, it is often by achieving stability of their disease and only half of patients are benefit from Avastin therapy due to lack of response to the treatment. Furthermore, there is no Avastin-response specific biomarker-based technologies to monitor anti-angiogenic therapies in the product development pipeline. Thus, development of noninvasive biomarkers of disease response and relapse is a crucial objective to aid in the management of patients. Rapid assessment of cancer response to a therapeutic regimen can determine efficacy early in the course of treatment. Early evaluation of cancer response to a therapeutic regimen can help adjust the efficacious treatment scheme, terminate ineffective treatments, minimizing unnecessary toxicity and expenditure. Recently, we applied phage display strategy and identified peptides that can selectively bind to tumors that respond to anti-angiogenic therapies. We identified a 12-mer peptide from phage display library that binds specifically to anti-angiogenic drug Avastin responsive tumors but not non-responsive or untreated tumors.This peptide was termed as Avastin- responsive peptide (AVRP). In this Phase I SBIR proposal, we will extend these efforts and further explore and develop clinically relevant AVRP specific probes for PET imaging monitoring tumor early response and efficacy to anti-tumor angiogenesis treatments. We will evaluate the ability of AVRP peptide to quantitatively measure tumor response to Avastin treatment in various tumor types and treatment regimens. We will also study the mechanism of AVRP action by identifying the target protein(s) of AVRP. Furthermore we will test a number of other therapies to determine whether suitably labeled AVRP peptide can be used as a universal probe to image cancer treatment efficacy in general. We will commercialize the product afterwe accomplish the SBIR project. The innovation in this proposal is to explore a novel strategy for developing efficient targeted imaging probes for monitoring tumor early response and efficacy to anti-angiogenic treatment. The success of this proposal will provide exciting promise to accelerate and reduce the cost of drug development, stratify patient populations, assess the treatment efficacy, and minimize the duration of treatment with ineffective regimens in cancer patients. PUBLIC HEALTH RELEVANCE: We will develop the clinically translatable novel molecular imaging probes for monitoring tumor early response and efficacy to anti-angiogenic treatment regimens. Rapid assessment of cancer response to a therapeutic regimen can determine efficacy earlyin the course of treatment. We anticipate that the new tracers will provide early evaluation of cancer response to a therapeutic regimen that can help accelerate the drug development, adjust the efficacious treatment scheme, reduce the healthcare cost, eventually leading to personalized cancer therapy, treatment monitoring, and dose optimization.

* information listed above is at the time of submission.

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