Developing a plectin-1 targeted imaging agent for the detection of pancreatic can

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$299,999.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA162845-01
Award Id:
n/a
Agency Tracking Number:
R43CA162845
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
PA10-050
Small Business Information
1076 AUTUMN HILL CT, CROZET, VA, 22932-3140
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
964923747
Principal Investigator:
GREG FRALISH
(434) 298-4844
gfralish@itihealth.com
Business Contact:
GREG FRALISH
(434) 298-4844
gfralish@itihealth.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): Pancreatic ductal adenocarcinoma (PDAC) is an intractable clinical problem, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. Currently, the standarddiagnostic course includes CT or MRI scans which do not have optimal sensitivity and specificity for accurately diagnosing and determining resectability status. The long-term objectives of this project are to develop an imaging agent that can sensitivelyand accurately detect pancreatic cancer. To that end, we are developing a targeted imaging agent to the newly identified pancreatic cancer cell surface biomarker plectin-1. Plectin-1 is specifically expressed in pancreatic cancer and not in benign inflamedconditions. It is upregulated during carcinogenesis and expressed at high levels in the advanced premetastatic PanIN III lesions. Moreover, a SPECT/CT plectin-1 targeted imaging agent has been developed and validated in numerous stringent mouse models. Experiments will be performed to optimize the imaging agent's molecular configuration and imaging modality. Outcomes will lead to a lead imaging product that will be advanced to phase II for commercial product development and clinical study. PUBLIC HEALTH RELEVANCE: The overall goal of this project is to develop new imaging approaches for the detection of pancreatic cancer, determine cancer resectability status and monitor response to chemotherapy. Alternative uses include early diagnostic screening inindividuals with high-risk for the development of pancreatic cancer. We will do this by chemically synthesizing imaging agents and testing them in mouse models of pancreatic cancer. We will also test whether PET or SPECT imaging has the best characteristics for imaging pancreatic cancer.

* information listed above is at the time of submission.

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