A Neonatal Cerebral Blood Flow Monitor based on MEMS Ultrasound

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$448,484.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
1R43HD069250-01
Award Id:
n/a
Agency Tracking Number:
R43HD069250
Solicitation Year:
2011
Solicitation Topic Code:
NICHD
Solicitation Number:
HD10-012
Small Business Information
SONETICS ULTRASOUND, INC. (Currently SONETICS ULTRASOUND, INC)
2864 Carpenter Rd. #100, ANN ARBOR, MI, 48108-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
130193829
Principal Investigator:
DAVID LEMMERHIRT
(734) 260-4800
dlemmerh@soneticsultrasound.com
Business Contact:
JENNIFER BAIRD
(734) 260-4800
jbaird@soneticsultrasound.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): The goal of the proposed program is to address several technical feasibility questions (in Phase I), and then demonstrate (in a subsequent Phase II) a safe, compact patch-like monitoring device for directly measuring blood flow to the brain in very low birth weight (VLBW, lt 1500gm) infants. In Phase I, the accuracy of 3D Doppler techniques will be evaluated for the vessel sizes and geometries specific to the neonatal brain, and the feasibility will be determined for implementing these techniques using a compact MEMS-based ultrasound transducer module. In Phase II, a full-scale transducer prototype will be developed and demonstrated in animal and/or clinical studies. Finally, in Phase III the monitoring hardware and software will be commercialized and translated to the clinical market, likely in partnership with manufacturers of existing neonatal monitoring equipment. The clinical market stands to benefit greatly from this innovation, given that nearly 64,000 VLBW infantsare born in the U.S. each year. Many of these fragile patients will sustain devastating brain injuries during the first days and weeks of life due to abnormal blood flow to the brain. Currently, brain injuries cause 5-10% of VLBW survivors to suffer from cerebral palsy and many more will develop cognitive or behavioral abnormalities in later life. Regular monitoring of blood flow to the neonatal brain would provide physicians the information needed to intervene early, reducing the likelihood of lasting injury. This would clearly have immense human benefit and would also reduce healthcare spending, given recent estimates that suggest the lifetime cost of care for each cerebral palsy patient will exceed 1M. PUBLIC HEALTH RELEVANCE: Potential benefits to public health from the successful development of Sonetics' novel ultrasound-based neonatal cerebral blood flow monitor include: higher survival rates for very low birth weight infants, reduced prevalence of cerebral palsy and other developmental problemsresulting from neonatal brain injuries, and reduced health-care costs for society as a whole. Furthermore, if accurate direct blood flow monitoring becomes more widely deployed, health outcomes will improve for additional patient populations such as thosewith peripheral arterial disease.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government