Device for Measuring Capillary Blood Flow and the Onset of Shock

Award Information
Agency:
Department of Health and Human Services
Amount:
$220,639.00
Program:
SBIR
Contract:
1R43HL106851-01A1
Solitcitation Year:
2011
Solicitation Number:
PA10-050
Branch:
N/A
Award Year:
2011
Phase:
Phase I
Agency Tracking Number:
R43HL106851
Solicitation Topic Code:
NHLBI
Small Business Information
RADIATION MONITORING DEVICES, INC.
44 HUNT ST, WATERTOWN, MA, -
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
073804411
Principal Investigator
 DAVID WOLF
 (617) 668-6810
 DWolf@RMDINC.COM
Business Contact
 NANCY MARSHALL
Phone: (617) 668-6810
Email: NMarshall@RMDInc.com
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The long-term goal of this proposal is to develop a sensor patch (CBFM) that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock. The sensor is based upon diffuse correlation spectroscopy (DCS). DCS measures fluctuations in red or near-infrared (NIR) light scattering as blood cells movein the capillary bed. Using correlation analysis, DCS extracts the characteristic time constants due to mean blood flow velocity. The device can also monitor heart rate, arterial or venal blood flow, and blood oxygenation. The aims of the proposal are: 1- Design and build a prototype CBFM, 2- Demonstrate the ability of the prototype device to measure capillary blood flow in pigs and determine whether capillary blood flow measurements are a good early indicator of the onset of hemorrhagic shock (hypovolemia), 3 - Create initial design of Phase II prototype, 4 - Write final report and Phase II proposal. PUBLIC HEALTH RELEVANCE: The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The goal of this proposal is to develop asensor patch that attaches to a patient's skin and continuously monitors capillary blood flow and, in conjunction with other monitors, predicts the onset of hemorrhagic shock.

* information listed above is at the time of submission.

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