Rapid-scanning optical-resolution photoacoustic microscopy

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL106855-01
Agency Tracking Number:
R43HL106855
Solicitation Year:
2011
Solicitation Topic Code:
NHLBI
Solicitation Number:
PA10-050
Small Business Information
MICRO PHOTO ACOUSTICS, INC.
60 BARKER DRIVE, STONY BROOK, NY, 11790-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
961855389
Principal Investigator:
JAY ZHAO
(631) 974-6268
Jay@a-optowave.com
Business Contact:
JAY XHAO
(631) 974-6268
Jay@a-optowave.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): We propose to develop rapid-scanning optical-resolution photoacoustic microscopy (OR-PAM), which is capable of label- free imaging of non-fluorescent optical absorbers. Optical absorption contrast is highly desirable for microvascular imaging and characterization because of the presence of endogenous strongly light-absorbing hemoglobin. The proposed imaging system can provide a 5-micron lateral resolution, a 15-micron axial resolution, a 1.2-mmimaging depth, and a 30-Hz B-scan frame rate. The following specific aims are proposed. Aim 1. System design and implementation: The proposed rapid-scanning OR-PAM is expected to outperform the current version in imaging speed by a factor of 10. Nearly diffraction-limited optical focusing is employed to achieve the lateral resolution. Absorption of the focused light produced photoacoustic waves due to thermoelastic expansion. Detection of the photoacoustic waves using a high-frequency focused ultrasonic transducer measures the internal light absorption distribution and hence provides a 3D mapping of the optical structure. OR-PAM is able to measure optical absorption with a relative sensitivity of 100%, the theoretical limit of any linear-effectimaging methods. Rapid scanning of the dual optical-ultrasonic foci is required to achieve a high imaging rate. Aim 2. Testing the imaging system in phantoms and living mice: The proposed OR-PAM system will be tested with phantoms and living mice to quantify the maximum imaging depth, spatial resolution, SNR, and the frame rate for B- scan imaging. PUBLIC HEALTH RELEVANCE: Microcirculation, the distal functional unit of the cardiovascular system, provides exchange sites for gases, nutrients, metabolic wastes, and thermal energy between the blood and the tissues. Pathologic microcirculation reflects the breakdown of homeostasis in organisms, which ultimately leads to tissue inviability. Therefore, the proposedin vivo microvascular imaging and characterization is of significant physiological, pathophysiological, and clinical importance.

* information listed above is at the time of submission.

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