Ultrasound-based molecular imaging probe for imaging acute myocardial syndromes

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HL110496-01
Agency Tracking Number: R43HL110496
Amount: $259,721.00
Phase: Phase I
Program: SBIR
Awards Year: 2011
Solicitation Year: 2011
Solicitation Topic Code: NHLBI
Solicitation Number: PA10-050
Small Business Information
TARGESON, INC.
3550 GENERAL ATOMICS CT, MS 02/444, SAN DIEGO, CA, 92121-
DUNS: 963312215
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JOSHUA RYCHAK
 (877) 290-4043
 joshua.rychak@targeson.com
Business Contact
 JOSHUA RYCHAK
Phone: (877) 290-4043
Email: JOSHUA.RYCHAK@TARGESON.COM
Research Institution
 Stub
Abstract
DESCRIPTION (provided by applicant): Acute coronary syndromes (ACS) account for an increasing level of healthcare expense although patient morbidity and mortality remain relatively high. Current methods for assessing the extent of cardiac ischemic injury in an acute setting offer limited sensitivity and specificity, which leads to both under- and over-treatment of patients with suspected ACS. In the current project, we propose to develop a novel molecular imaging probe for visualization of recent myocardialischemia using echocardiography. Specifically, we aim to develop a microbubble contrast agent targeted to a molecular marker of recent ischemia. We have identified a novel targeting ligand, and developed a biocompatible coupling chemistry suitable for translation to human use. We will validate ligand conjugation and microbubble stability, and assess the targeting efficacy of the resultant microbubble formulations in vitro and in a mouse model of ischemic memory. Successful completion of these aims will result in a molecular imaging probe that may be used to accurately and rapidly identify patients with recent myocardial ischemia. PUBLIC HEALTH RELEVANCE: Imaging of recent ischemia is a critical unmet need in cardiac care. In the current project, we aim to develop a diagnostic imaging test for detecting recent myocardial ischemia using ultrasound imaging. Success in this project will enable rapid identification of patients who would benefit from myocardium-sparing treatments, and eliminate unnecessaryhospitalizations for patients who have not experienced an ischemic event.

* information listed above is at the time of submission.

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