Portable Brian Injury Biomarker Detection System with Integrated Microdialysis Pr

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$165,780.00
Award Year:
2011
Program:
SBIR
Phase:
Phase I
Contract:
1R43NS076167-01
Award Id:
n/a
Agency Tracking Number:
R43NS076167
Solicitation Year:
2011
Solicitation Topic Code:
NINDS
Solicitation Number:
PA10-050
Small Business Information
534 W. Research Blvd, Suite 260, FAYETTEVILLE, AR, 72701-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
125518428
Principal Investigator:
CHAMPAKDAS
(479) 527-6810
champak.das@sfc-fluidics.com
Business Contact:
SAIKUMAR
(479) 527-6810
sai.kumar@sfc-fluidics.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): Portable brain injury biomarker detection system with integrated microdialysis probe Project summary/Abstract: This SBIR application aims to integrate microdialysis with an effective, miniature pumping system and adetection system for analyzing different biomarkers in real-time and without user intervention. An integrated portable device consisting of SFC Fluidics' proprietary ePump(R), snap-on magnetic latches for rapid fluidic connection, a reagent reservoir and amicrofluidic detection system will be developed. This system will facilitate real time continuous monitoring of pathological biomarkers, which in turn helps in better patient management over the course of healing/therapy. The focus of this SBIR is on monitoring Traumatic Brain Injury (TBI) sequelae with a microdialysis based system using a set of low molar mass biomarkers and a leading large molecule (protein) biomarker. In Phase I, commercially-available ELISA kits will be incorporated into SFC Fluidics integrated microdialysis and fluid handling system. The Phase II focus will be on development of a single prototype system that can quantify multiple TBI biomarkers. Phase I Research Plan Specific Aim: Design and engineer brain injury biomarker detection system with integrated microdialysis probe Task 1: Design and fabricate ePump driven integrated flow system Task 2: Detection of small molecule brain injury biomarkers Task 3: Detection of large molecule brain injury biomarker PUBLIC HEALTH RELEVANCE:An estimated 1.7 million Traumatic Brain injury (TBI) cases are reported every year in United States with 80.7 percent of them resulting in emergency department visits. There is an urgent need for development of a portable, microdialysis system with in-built analyzer which will help in rapid and continuous diagnosis of the state of health of a patient with TBI. Early and timely diagnosis of the pathological condition will help a doctor to take remedial actions and improve the quality of care of the patient while greatly mitigating long-term complications.

* information listed above is at the time of submission.

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