Novel Catalytic MetalloDrug Targeting IRES RNA for Treatment of HCV Infection

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$2,004,496.00
Award Year:
2011
Program:
SBIR
Phase:
Phase II
Contract:
2R44AA016712-03A2
Agency Tracking Number:
R44AA016712
Solicitation Year:
2011
Solicitation Topic Code:
NIAAA
Solicitation Number:
PA09-095
Small Business Information
METALLOPHARM, LLC
1790 Riverstone Drive, Delaware, OH, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
140535845
Principal Investigator:
ADA COWAN
(740) 815-9851
metallopharm@gmail.com
Business Contact:
JAMES COWAN
(740) 815-9851
metallopharm@gmail.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): HCV is responsible for 60% of the cases of chronic hepatitis and 50% of cases of cirrhosis, end- stage liver disease, and liver cancer. An effective vaccine has proved elusive and the preferred therapy with pegylated interferon is effective in less than 50% of patients with genotype 1 and 75% of patients with genotypes 2 or 3. Clearly, new treatment alternatives are needed. Interest in HCV IRES RNA as a drug target is reflected by the increasing number of small and largepharma companies pursuing that goal. MetalloPharm has created a novel platform technology (metallodrugs) that has the potential to irreversibly destroy the HCV IRES RNA. The specific aims are directed toward selection of a lead and back-up drug candidatefor IND-enabling pre- clinical testing following validation of cellular mode of action against IRES RNA and uptake mechanisms; assessment of PK, toxicity and efficacy data; and exploration of methods to improve serum half life. PUBLIC HEALTH RELEVANCE: Millions of people worldwide are infected with HCV, including a significant portion of the US population. HCV is responsible for 60% of the cases of chronic hepatitis and 50% of cases of cirrhosis, end-stage liver disease, and liver cancer. An effective vaccine has proved elusive and current therapy is effective in less than 50% of patients. Clearly, new treatment alternatives are needed. MetalloPharm has created a novel class of therapeutics (metallodrugs) that function by destroying a key molecule inthe viral life cycle with the potential to halt the progression of, or completely eliminate the virus.

* information listed above is at the time of submission.

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